ReSure® Sealant

ReSure Sealant is indicated for intraoperative management of clear corneal incisions (up to 3.5mm) with a demonstrated wound leak for which a temporary dry surface can be achieved, in order to prevent postoperative fluid egress from such incisions following cataract surgery with intraocular lens (IOL) placement in adults.

ReSure Sealant is a biocompatible hydrogel which is prepared and applied in approximately 20 seconds, protecting incisions in the immediate post-operative period by creating a watertight seal when wounds are most vulnerable. The hydrogel conforms to the de-epithelialized tissue, adheres to surface irregularities, and gradually sloughs off in tears during reepithelialization, so there is no need for removal.

Benefits of ReSure Sealant

Dr. Terry Kim showing the application of ReSure Sealant following a complex cataract surgery


WARNINGS

ReSure Sealant should not be used on actively leaking incisions in which a temporary dry ocular surface cannot be achieved.

Do not use in patients who are allergic to FD&C Blue #1.

PRECAUTIONS

ReSure Sealant is for single-use only; discard open and unused product. Use within 30 minutes of removing the mixing tray from foil pouch.

Prior to application, ensure incision site is not actively leaking; remove any standing moisture from the surrounding ocular surface and incision and ensure the site is dry.

Prophylactic use of ReSure Sealant on corneal incisions without intraoperative leakage was not evaluated in the clinical study.

ReSure Sealant will not replace the need for sutures in certain circumstances, including the need for long-term mechanical support to the incision.

ADVERSE REACTIONS

The most commonly reported (≥1%) ocular adverse events that occurred in patients treated with ReSure Sealant in the pivotal trial included: worsening best corrected visual acuity (7%), increase in intraocular pressure (5%), corneal astigmatism (3%), eye pain (3%), posterior vitreous detachment (2%), and anterior chamber inflammation (1%).

Please see full instructions for use.

Application of ReSure Sealant

Application of ReSure Sealant

 

Clinical Image - Primary clear corneal incision site remained unsealed despite stromal hydration

Primary clear corneal incision site remained unsealed despite stromal hydration.

 

Clinical Image - ReSure Sealant selectively adheres to the de-epithelialized tissue and seals the wound

ReSure Sealant selectively adheres to the de-epithelialized tissue and seals the wound.


OCT images of the cornea courtesy of Deepinder Dhaliwal, M.D.

 

References: 1. Masket S, Hovanesian JA, Levenson J, et al. J Cataract Refract Surg. 2014;40(12):2057-2066. 2. Matossian C, Makari S, Potvin R. Clin Ophthalmol. 2015;9:921-928.